Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.

DKO transplanted animals exhibited also a highly significant increase in the amount of foam cells compared to control animals (2.88±0.19% [n = 5] compared to WT 0.20±0.07% [n = 7]; p<0.01), which, however, was less severe than in single ABCA1 KO transplanted mice (p<0.001) ( Fig. 3A ).

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Single ABCA7 deficiency did show an increase in CD4 + T helper cells, which, however, failed to reach significance (29±0.4% compared with 25±0.5% in WT transplanted animals; p>0.05).

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