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Extensively drug-resistant tuberculosis, Pakistan.

Emerg Infect Dis · 2010 · PMC3294979 · PMID 20735937

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an increasing trendno p-value reported
This study documents an increasing trend of XDR resistance within MDR TB isolates in Pakistan.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.