Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.

This analysis showed a highly significant running enrichment score because the genes identified by LRH-1 ChIP-seq that overlap with FXR binding peaks were preferentially located toward the top of the differentially expressed gene list ranked by fold change in gene expression (Figure 8 , p = 1.06e -07 ).

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