Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.

Interrelationships between insulin dose at 36 weeks, IGF-I bioactivity and total IGF-I At 36 weeks, there was a highly significant inverse relationship between insulin dose and serum total IGF-I in both groups (total insulin dose: G+MET group, r = −0.36, p = 0.007; NPH+MET group, r = −0.41, p = 0.005; insulin dose/kg: G+MET group r = −0.33, p = 0.01; NPH+MET group r = −0.36, p = 0.02), (Fig. 3 ).

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