Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

J Med Chem · 2012 · PMC3297363 · PMID 22364416

Europe PMC DOI

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a definite trendno p-value reported

In the case of monocyclic compounds, there is a definite trend toward better activity when CF 3 groups are present in the side chain and when a chlorine atom is present at the 3-position.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.