Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture.

In this regard it may be significant that AAA+ proteins function as multimeric assemblies, with the ATPase active sites formed at the interface of protomers.

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Second iteration psiBLAST searches of the NCBI database using the Tb13380-predicted polypeptide sequence (713 amino acid residues) identified Drosophila melanogaster (Dme)Orc4 (E-value, 9e-14), and then Orc4 subunits from further organisms at lower, yet highly significant, expectancy values (0.003≤E-value≤1e-13).

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