Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters.

In addition, a nonsignificant trend of higher semen volume (3.9 vs. 3.4–3.5 ml; P = 2.60 × 10 −1 ) but lower sperm concentration (42 vs. 63 million/ml; P = 1.27 × 10 −1 ) and total sperm count per ejaculate (162 million vs. 220 million; P = 5.46 × 10 −1 ) was observed among TT subjects.

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The T-allele of rs10835638 exhibited highly significant association with reduced serum FSH in Estonian studies of young men and male partners of infertile couples ( 2 , 3 ).

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