Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles.

Particle size increased in the pH range 8.0-5.5 followed by a decreasing trend (Figure 7 ), fitting a second order polynomial (quadratic) relationship (R 2 > 0.9) between pH and particle size of P/12-NH-12/L.

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