High-grade ER-negative tumour breast cancers are characteristic of both very young onset cases and patients with hereditary breast cancer

Breast Cancer Res · 2006 · PMC3300274

Europe PMC

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a nonsignificant trendno p-value reported

Compared with women with no family history, women falling into the 10% of the cohort estimated from family history to be most likely to carry BRCA1 or BRCA2 gene mutations, high genetic risk women had significantly more grade 3 tumours ( P < 0.001) and a nonsignificant trend towards more ER-negative tumours.

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