Multivariate analysis of different prognostic factors in HER2 + and HER2 - subsets indicated that grade is the most important factor, followed by nodal status, lymphoid infiltration and tumor size in HER2-negative breast carcinomas, whereas nodal status was the most important prognostic factor, with tumor size showing only borderline significance, in the HER2-positive group.
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Identification of HER2-positive breast carcinomas as a particular subset with peculiar clinical behaviours
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