Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia.

PLoS One · 2012 · PMC3302843 · PMID 22428001

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The cellular sulfated GAG and C4S content are inversely and linearly related to the ARSB activity, including at baseline, and following hypoxia, silencing, and overexpression in the BEC and the NCM460 cells with highly significant inverse correlation (r = −0.99) ( Fig. 3C, 3D ).

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