The 3'-terminal hexamer sequence of classical swine fever virus RNA plays a role in negatively regulating the IRES-mediated translation.

PLoS One · 2012 · PMC3303849 · PMID 22432046

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highly significantno p-value reported

CSF is highly contagious and often causes fatal hemorrhagic disease in pigs, resulting in highly significant economic losses worldwide [2] , [3] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.