Pharmacological isolation of whole-cell BK channel current revealed that CA3 neurons in β4 knock-out animals showed a highly significant, more than 2.5-fold increase in BK channel current amplitude compared to heterozygote littermates (paxilline-sensitive current in β4 +/− mice: 1.62±0.32 nA; n = 11 cells versus β4 −/− mice 3.51±0.59 nA; n = 12 cells; p = 0.01, Figure 6C,D ).
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The brain-specific Beta4 subunit downregulates BK channel cell surface expression.
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