Extensive genetic diversity, unique population structure and evidence of genetic exchange in the sexually transmitted parasite Trichomonas vaginalis.

Breaking the three genes into linkage groups, we find that type 1 sequences have a non-significant I A S (I A S = 0.0296, p = 0.153), while type 2 is marginally non-significant (I A S = 0.0598, p = 0.057), and becomes significant when the classical Index of Association (I A ) is calculated (I A = 0.1195, p = 0.046).

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However, a highly significant difference was found in the minimum lethal concentration (MLC) of metronidazole necessary to kill isolates of the two types, with type 2 isolates demonstrating a mean MLC of 228.4 μg/ml of metronidazole, while type 1 isolates exhibited a mean MLC of 76.6 μg/ml of metronidazole.

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