Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism.

On the contrary, the increases in both MBV and MBF induced by GLP-1 were highly significant compared with either the saline ( P = 0.001 for MBV and 0.01 for MBF), l -NAME ( P < 0.001 for both MBV and MBF), or l -NAME plus GLP-1 ( P < 0.001 for both MBV and MBF) group ( Fig. 3 ).

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Inasmuch as there appeared to be a decreasing trend in both MBV and MBF during l -NAME infusion, there was no statistically significant difference in MBV, MFV, and MBF between the l -NAME group and the saline group ( P > 0.05 for all, two-way repeated-measures ANOVA).

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