Compensatory T-cell regulation in unaffected relatives of SLE patients, and opposite IL-2/CD25-mediated effects suggested by coreferentiality modeling.

However, aTreg cell frequencies had highly significant positive correlations with the band numbers of IgG autoantibodies reactive toward HEp2 nuclear and cytoplasmic proteins when calculated within the SLE-unaffected relatives group ( Fig. 3 , Table 2 ), in contrast to SLE patients or unrelated control subjects.

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