Although no genes identified by us were significantly confirmed by the WTCCCHS data (Caucasian), COMMD7 , which encodes COMM domain-containing protein 7 on 20q11.21, was replicated with a borderline significance (pFDR LRC = 7.46×10 −2 ).
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Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
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GRB14 , TMEM56 and KIAA1797 exhibited highly significant differential allelic and expressed distributions between hypertensive patients and normotensive controls.
However, we observed that some genomic regions contained a significant proportion of SNPs with marginal significance ( Figure S2A – S2D ).