Gastrin-releasing peptide signaling plays a limited and subtle role in amygdala physiology and aversive memory.

When compared to the saccharin-exposed animals that received NaCl injections, two factor ANOVA (factors: genotype, treatment) indicated that there was no significant difference in aversion index (AI) on day 1 between WT and GRPR KO mice (F (1,42) = 0.95; p>0.3), no genotype×treatment interaction (F (1,42) = 0.31; p>0.5), but a highly significant difference in AI between the groups that received LiCl versus NaCl injections (F (1,42) = 739.6; p<0.001, Fig. 5A ).

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