Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study.

This was confirmed in quadratic multilevel models in which the interaction term risk-allele-score × age 2 was highly significant for BMI and weight SDS to age 53 y (both P < 0.001).

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Results: The obesity-risk-allele score showed borderline significant association with birth weight (0.019 SDS/allele; P = 0.05) and was more clearly associated with higher weight and BMI at all time points between ages 2 and 53 y; the strongest associations with weight occurred at ages 11 and 20 y (both 0.056 SDS/allele).

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