The area under the curve of the glucose tolerance test was decreased in the high fat-fed MIC-1/GDF15 transgenic mice compared to corresponding control mice, but this fell just short of statistical significance ( Fig. 4B ).
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Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets.
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