Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes.

Tumor growth was inhibited in the two groups of FTS-treated mice, and by day 21 the decrease in tumor volume in both of these groups relative to the vehicle-treated control was highly significant (decrease of 70.25%±19% in the first (anti-CD25 Ab-treated) group (p<0.05) and 64.69%±15.6% (p<0.05) in the second (anti-IgG1 Ab-treated) group; Figure 3A ).

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