Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.

Br J Cancer · 2012 · PMC3326676 · PMID 22491422

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highly significantno p-value reported

A431 cells stably transduced with a DUSP6-shRNA plasmid exhibited a less dramatic but still highly significant reduction in DUSP6 protein levels (∼60% reduction).

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