MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.

J Exp Med · 2012 · PMC3328367 · PMID 22430491

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likely to be significantno p-value reported

This level of BIM up-regulation is likely to be significant because BIM up-regulation induces apoptosis unless its activity is concomitantly suppressed by overexpression of antiapoptotic BCL-2 family members ( O’Connor et al., 1998 ).

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