Dynamic lactate indices as predictors of outcome in critically ill patients.

• We demonstrated that higher lactate averaged over 24 hours (LAC TW24 ) and an increasing trend in lactate concentration over 24 hours (LAC Δ24 ) is associated with greater hospital mortality. • Furthermore, the combination of these markers out-performed all individual 'static' indices of lactate homeostasis in predicting outcome in the critically ill. • Clinicians should be especially alert

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