Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity.

By cotransfecting human SRY (encoded on the male Y chromosome), the efficiency of the 420M9-1395 intronic region to drive transcription was reduced by around 15% ( Figure 5 ), and the combination of both SRY and the novel haplotype further reduced expression over wild type at a trend level of significance ( t =1.7675, df=9, P =0.055).

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