highly significantP < 0.001
Identification of the Most Effective Mutation among CARD15/NOD2 (Leu1007fsinsC, Arg702Trp, Gly908Arg), TLR4 Thr399Ile and CD14 −159C/T Comparing the significance of each single mutation against the other mutations studied showed that the CARD15/NOD2 Leu1007fsinsC was more effective than TLR4 Thr399Ile, and the difference was highly significant ( P < 0.001); additionally, CARD15/NOD2 Arg702Trp was more effective than the TLR4 Thr399Ile, and the difference was highly significant ( P = 0.002).