Comprehensive linker-scanning mutagenesis of the hepatitis C virus E1 and E2 envelope glycoproteins reveals new structure-function relationships.

Likewise, there was a highly significant reduction in binding ( P <0.01) of all eight mAbs with mutants in 540 and in 549 ( Fig. 2 and Table 2 ), showing that this region, which forms part of the central DI domain in the model ( Fig. 6 ), is also essential for correct protein folding.

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