Barely Significant
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The role of cytokines and hot flashes in perimenopausal depression.

Ann Gen Psychiatry · 2012 · PMC3348044 · PMID 22490187

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a decreasing trendno p-value reported
an increasing trendno p-value reported
However, it should be noted that for serum levels of TNFα there is an increasing trend and for levels of IL-6 there is a decreasing trend in the two subgroups of perimenopausal women with depression (treated and not treated with SSRIs) when compared to perimenopausal women without depression.

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