Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

There was either a significant decrease in the nitrite production of group treated with 3.12 μM inotilone ( p <0.05) or very or highly significant decrease of groups treated respectively with 6.25, 12.5 and 25 μM of inotilone when compared with the LPS-alone group ( p <0.01 or p <0.001).

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