The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function.

Other metabolites of note were (i) glutamine and glutamate, both of which were significantly increased in uptake from conditioned media and had significantly increased intracellular levels in NSC-134754-treated cells compared with controls ( P <0.05) and (ii) intracellular choline metabolites, of which a highly significant ( P <0.01) increase in glycerophosphocholine and significant ( P <0.05) decrease in phosphocholine was determined in the treated cells (data not shown).

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