Imaging-genetics in autism spectrum disorder: advances, translational impact, and future directions.

The potential role for DISC1 in risk for mental illness was first identified based on a balanced chromosomal t(1;11) translocation that disrupted the DISC1 protein sequence, and segregated in a highly significant manner with schizophrenia, bipolar disorder, and major depression, in a large and unique Scottish family (Millar et al., 2000 ; Blackwood et al., 2001 ).

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