Dendritic cell generation and CD4+ CD25high FOXP3+ regulatory t cells in human head and neck carcinoma during radio-chemotherapy.

Following maturation of the cells with TNFα, CD14 expression was almost absent (0.8 ± 0.2%), whereas CD83 was up-regulated (38.8 ± 10.6% CD83 + cells), indicating maturation of DC However, the ability of DC to mature in HNSCC patients (n = 6) appeared to negatively correlate with the frequency of CD4 + CD25 high FOXP3 + Treg before RCT, with a trend towards significance (Figure 5 ).

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