However, a number of key genes did show highly significant temporal changes in Bdr mice when compared to wild-types, including the SCN neuropeptides arginine vasopressin ( Avp ), neurotensin ( Nts ), and tachychinin 1/substance P ( Tac1 / Sp ) ( Table S4 ), all genes whose protein products have been variously implicated as SCN output signals but whose specific function is unclear [ 22, 23 ].
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