The effective diffusion of PTP1B D/A in the ER was three-fold lower than that of PTP1B WT: 0.070 + 0.003 μm 2 /s, with a highly significant immobile fraction of 0.28 + 0.02 (n = 13).
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Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B.
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