Genetically encoded proton sensors reveal activity-dependent pH changes in neurons.

Front Mol Neurosci · 2012 · PMC3364509 · PMID 22666186

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Using this epilepsy model, we were able to demonstrate that the genetic pH reporters E 2 GFP and deGFP4 are able to detect a highly significant negative shift in pH during epileptiform activity (E 2 GFP: P < 10 −10 , n = 40, deGFP4: P < 10 −7 , n = 19, paired t test).

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