Diametrically opposite methylome-transcriptome relationships in high- and low-CpG promoter genes in postmitotic neural rat tissue.

Epigenetics · 2012 · PMC3368807 · PMID 22415013

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp≈1.0x10 −74actually significant

We performed reduced representation bisulfite sequencing (RRBS), 5 a technology for interrogating hundreds of thousands of methylation sites with digital precision 27 , 28 on the rat PNS and found characteristic and highly significant patterns relating gene methylation and activity (p≈1.0x10 −74 ) that differed markedly between LCP and HCP genes.

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