Barely Significant
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Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.

PLoS One · 2012 · PMC3368838 · PMID 22701695

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highly significantno p-value reported
The antitumor and protective effects of jacaranone are highly significant at low therapeutic doses.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.