Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery.

Although there was a slight trend toward somewhat increased inhibition for some combinations, none of these differences were statistically significant, and under no conditions did any combinations of siRNAs result in a higher inhibition rate than the inhibition rate caused by Pol-si2 when applied alone (Supplementary Fig. 5). 3.5 SiRNAs increase the viability of infected cells to different extents Next, we quantitatively assessed the impact of Ad5 gene silencing on the viability of infected cultures.

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