Online availability and safety of drugs in shortage: a descriptive study of internet vendor characteristics.

J Med Internet Res · 2012 · PMC3374535 · PMID 22321731

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The sentences

a worrying trendno p-value reported

Indeed, drug shortages have tripled in the last 6 years, while few have left the list, portraying a worrying trend [ 3 ], while the global nature of the problem has become increasingly dire [ 49 , 50 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.