Barely Significant
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A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery.

PLoS Genet · 2012 · PMC3375262 · PMID 22719266

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hedged sentence
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closest p · 0.0× alpha
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boldest claim

The sentences

highly significantp = 1.8×10 −42actually significant
Segregation analysis gave a highly significant association between the C allele and disease (p = 1.8×10 −42 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.