The Pathogenic Role of the Adaptive Immune Response to Modified LDL in Diabetes.

This is extremely significant, because, as previously mentioned, 95% or more of the modified LDL in circulation is associated with the corresponding antibodies forming IC (Virella et al., 2004 ), and because IC containing modified LDL are considerably more pathogenic than modified LDL by itself as consequence of their ability to engage Fcγ receptors and activate phagocytic cells to a much greater extent (Virella et al., 2002 ; Saad et al., 2006 ).

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