The surfactant protein C mutation A116D alters cellular processing, stress tolerance, surfactant lipid composition, and immune cell activation.

BMC Pulm Med · 2012 · PMC3376036 · PMID 22458263

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highly significantno p-value reported

While no difference in surface receptor expression between WT and mutant was observed in CD8+ lymphocytes, CD4+ lymphocytes showed a highly significant increase in the level of surface receptor CCR2 expression in response to the supernatant of SP-C A116D expressing cells (Figure 6A ).

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