However, mild-moderate eczema shows a lower odds ratio than moderate-severe eczema and its association with FLG null mutations may be significant only in individuals carrying two null mutations ( Brown et al. , 2008a ).
2
—
—
The sentences
The strong and highly significant association of FLG null mutations with atopic eczema has subsequently been replicated in over 20 independent studies, including case/control studies, family studies and unselected population cohorts.