Clinical features of dengue in a large Vietnamese cohort: intrinsically lower platelet counts and greater risk for bleeding in adults than children.

To assess relationships between platelet counts and onset of mucosal bleeding in more detail in this group, we compared the most recent counts measured prior to development of any mucosal bleeding (≤24 hours) with counts measured at the same time in the disease evolution for patients who never developed mucosal bleeding ( Figure 4 ); the counts were significantly lower in those who developed mucosal bleeding on days 5 and 6 of illness (p = 0.03 and p<0.001, respectively) and borderline significant for day 4 (p = 0.06, all Mann-Whitney test).

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