at the limit of significancep < 7.0 × 10 -2
Moreover, using the one side Z-test as test for proportion it was found that: i) regarding the Blue category, the gene frequency of the functional classes B and J was significantly higher in H3- ( p < 2.8 × 10 -2 and p < 2.4 × 10 -2 , respectively), that of class A showed the same trend (but at the limit of significance, p < 7.0 × 10 -2 ), whereas the functional classes K and L, although having the same trend, did not show significant p -values; ii) regarding the Black category, three out of seven functional classes, namely T, W and O, were significantly higher in the H3+ bands ( p < 2.8 × 10 -10 , p < 1.0 × 10 -6 and p < 5.6 × 10 -2 , respectively), whereas the remaining classes showed no trend; finally iii) regarding the Red category, five out of eight functional classes showed a significantly different distribution between the chromosomal bands H3- and H3+, but a non uniform trend was observed.