Investigation of the transcriptional regulation underlying these gene expression differences by transcription factor binding site analysis of genes which were more highly expressed by more than eight-fold in AM, showed highly significant enrichment for NF-κB family members ( Table 2 ), which are key regulators of pro-inflammatory gene expression.
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Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation.
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