The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.

Canonical pathway modelling of the genes most significantly altered in association with the 9p21.3 risk locus in myocardial and vascular tissues combined, identified a highly significant association with the cell cycle G1 phase progression pathway (p-value from canonical pathway modelling: 1.08×10 −258 , Figure 3 ), in which proteins encoded by CDKN2A and CDKN2B (p16 and p15, respectively) play an important regulatory role.

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