mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis.

It may be significant that HSF1 requires glutamine for activity (essential for mTORC1), promotes translation, one of the earliest findings in study of HSP expression [19] – [20] .

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The heat shock response is highly significant in human pathology, as HSP levels increase in cancer and promote tumorigenesis and decline in protein aggregation disorders such as Alzheimer’s disease, a lesion that permits accumulation of lethal protein inclusion bodies [3] – [6] .

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