Relative to infected wild type animals, overexpression of wild type HIF-1 in infected animals caused significant repression of oac-31 , C23G10.11 , and tre-5 , and an overall trend towards repression of both egl-9- repressed and -induced genes (10 out of 18 genes, Figure 5A ), suggesting that overexpression of HIF-1 is sufficient to cause gene expression changes.
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EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.
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