While the number of nNOS neurons in the neocortex is small, their impact on the neocortical network through NO release might be significant as they are highly ramified, and project long distances rostro-caudally and medio-laterally, connecting neocortical areas up to 6–8 mm apart (Tomioka et al., 2005 ).
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The origin of neocortical nitric oxide synthase-expressing inhibitory neurons.
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